Molecular Dermatology

Our laboratory performs translational research mainly in onco-dermatology with an emphasis on cutaneous T-cell lymphoma (CTCL). We work in tight collaboration with dermatologists from Rabin Medical Center, with access to samples from human subjects. CTCL is a heterogeneous group of malignancies derived from skin-homing T-cells. The most common types are mycosis fungoides (MF) and its leukemic form, Sezary syndrome. The aim of our research is to gain further insight into the genetics, epigenetics, cell biology, immunology and the tumor microenvironment underlying the development and progression of CTCL in order to promote the development of novel drugs and therapeutic modalities, including a search for potent cannabis extracts and new immune blockade. Recently, we have extended our work to non-melanoma skin cancers such as cutaneous squamous cell carcinoma (cSCC) and actinic keratosis (AK).