Ophthalmology
Felsenstein Medical Research Center

Eye Research

Ophthalmology

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Eye Research

Publications

2016

  • The effects of the apoE4 genotype on the developing mouse retina.
    Maharshak I, Salomon-Zimri S, Antes R, Liraz O, Nisgav Y, Livnat T, Weinberger D, Colton CA, Solomon AS, Michaelson DM.
    Exp Eye Res. 2016 Apr;145:17-25. doi: 10.1016/j.exer.2015.11.001. Epub 2015 Nov 7. PMID: 26554939.
    למחקר
  • Bevacizumab clearance through the iridocorneal angle following intravitreal injection in a rat model.
    Gal-Or O, Dotan A, Dachbash M, Tal K, Nisgav Y, Weinberger D, Ehrlich R, Livnat T.
    Exp Eye Res. 2016 Apr;145:412-416. doi: 10.1016/j.exer.2016.02.006. Epub 2016 Feb 26. PMID: 26923799.
    למחקר
  • Efficacy of topical aflibercept versus topical bevacizumab for the prevention of corneal neovascularization in a rat model.
    Sella R, Gal-Or O, Livny E, Dachbash M, Nisgav Y, Weinberger D, Livnat T, Bahar I.
    Exp Eye Res. 2016 May;146:224-32. doi: 10.1016/j.exer.2016.03.021. Epub 2016 Mar 26. PMID: 27020759.
    למחקר
  • Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model.
    Dotan A, Kremer I, Gal-Or O, Livnat T, Zigler A, Bourla D, Weinberger D.
    J Vis Exp. 2016 Apr 3;(110):e53201. doi: 10.3791/53201. PMID: 27077753; PMCID: PMC4841336.
    למחקר
  • Knockdown of unc119c results in visual impairment and early-onset retinal dystrophy in zebrafish.
    Rainy N, Etzion T, Alon S, Pomeranz A, Nisgav Y, Livnat T, Bach M, Gerstner CD, Baehr W, Gothilf Y, Stiebel-Kalish H.
    Biochem Biophys Res Commun. 2016 May 13;473(4):1211-1217. doi: 10.1016/j.bbrc.2016.04.041. Epub 2016 Apr 11. PMID: 27079236.
    למחקר
  • Efficacy of Subconjunctival Aflibercept Versus Bevacizumab for Prevention of Corneal Neovascularization in a Rat Model.
    Gal-Or O, Livny E, Sella R, Nisgav Y, Weinberger D, Livnat T, Bahar I.
    Cornea. 2016 Jul;35(7):991-6. doi: 10.1097/ICO.0000000000000849. PMID: 27124775.
    למחקר
  • The small tellurium-based compound SAS suppresses inflammation in human retinal pigment epithelium.
    Dardik R, Livnat T, Halpert G, Jawad S, Nisgav Y, Azar-Avivi S, Liu B, Nussenblatt RB, Weinberger D, Sredni B.
    Mol Vis. 2016 May 28;22:548-62. PMID: 27293373; PMCID: PMC4889158.
    למחקר

2017

  • Effect of Histone Deacetylase Inhibitor, Butyroyloxymethyl-Diethyl Phosphate (AN-7), on Corneal Neovascularization in a Mouse Model.
    Schaap-Fogler M, Bahar I, Rephaeli A, Dahbash M, Nudelman A, Livny E, Barliya T, Nisgav Y, Livnat T.
    J Ocul Pharmacol Ther. 2017 Jul/Aug;33(6):480-486. doi: 10.1089/jop.2016.0017. Epub 2017 Mar 24. PMID: 28338404.
    למחקר
  • Changes in Retinal Function and Cellular Remodeling Following Experimental Retinal Detachment in a Rabbit Model.
    Barliya T, Ofri R, Sandalon S, Weinberger D, Livnat T.
    J Ophthalmol. 2017;2017:4046597. doi: 10.1155/2017/4046597. Epub 2017 Apr 9. PMID: 28491466; PMCID: PMC5401754.
    למחקר
  • Correlation between Interleukin-6 and Thrombin-Antithrombin III Complex Levels in Retinal Diseases.
    Ehrlich R, Zahavi A, Axer-Siegel R, Budnik I, Dreznik A, Dahbash M, Nisgav Y, Megiddo E, Kenet G, Weinberger D, Livnat T.
    Curr Eye Res. 2017 Sep;42(9):1269-1272. doi: 10.1080/02713683.2017.1313432. Epub 2017 Jun 20. PMID: 28632410.
    למחקר
  • Mobile Laser Indirect Ophthalmoscope: For the Induction of Choroidal Neovascularization in a Mouse Model.
    Weinberger D, Bor-Shavit E, Barliya T, Dahbash M, Kinrot O, Gaton DD, Nisgav Y, Livnat T.
    Curr Eye Res. 2017 Nov;42(11):1545-1551. doi: 10.1080/02713683.2017.1349154. Epub 2017 Sep 21. PMID: 28933966.
    למחקר
  • Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients.
    Barliya T, Dardik R, Nisgav Y, Dachbash M, Gaton D, Kenet G, Ehrlich R, Weinberger D, Livnat T.
    Mol Vis. 2017 Dec 13;23:922-932. PMID: 29296072; PMCID: PMC5741378.
    למחקר

2018

  • Retinal Penetration of Intravitreally Injected Tissue Plasminogen Activator: A Rat Model Study.
    Tal K, Dotan A, Nisgav Y, Dachbash M, Gal-Or O, Ehrlich R, Gaton DD, Weinberger D, Livnat T.
    Ophthalmic Res. 2018;59(4):235-240. doi: 10.1159/000477621. Epub 2017 Jul 20. PMID: 28728144.
    למחקר
  • Transcleral approach for closing retinal tears using DuraSeal™ hydrogel sealant.
    Barliya T, Sandalon S, Ofri R, Livnat T, Weinberger D.
    Indian J Ophthalmol. 2018 Feb;66(2):238-243. doi: 10.4103/ijo.IJO_758_17. PMID: 29380766; PMCID: PMC5819103.
    למחקר

2019

  • The Histone Deacetylase Inhibitor AN7, Attenuates Choroidal Neovascularization in a Mouse Model.
    Dahbash M, Sella R, Megiddo-Barnir E, Nisgav Y, Tarasenko N, Weinberger D, Rephaeli A, Livnat T.
    Int J Mol Sci. 2019 Feb 7;20(3):714. doi: 10.3390/ijms20030714. PMID: 30736437; PMCID: PMC6387404.
    למחקר
  • Ocular Effects of Sildenafil in Naïve Mice and a Mouse Model of Optic Nerve Crush. Invest
    Zahavi A, Weiss S, Vieyra M, Nicholson JD, Muhsinoglu O, Barinfeld O, Zadok D, Goldenberg-Cohen N.
    Ophthalmol Vis Sci. 2019 May 1;60(6):1987-1995. doi: 10.1167/iovs.18-26333. PMID: 31063183.
    למחקר
  • Comparison of Subconjunctival Aflibercept and Betamethasone for the Treatment of Formed Corneal Neovascularization in a Rabbit Model.
    Eiger-Moscovich M, Livny E, Sella R, Gal-Or O, Nisgav Y, Livnat T, Bahar I.
    Ophthalmic Res. 2019;62(2):116-122. doi: 10.1159/000499165. Epub 2019 May 21. PMID: 31112967; PMCID: PMC6878856.
    למחקר
  • Activated protein C induces suppression and regression of choroidal neovascularization- A murine model.
    Livnat T, Weinberger Y, Budnik I, Deitch I, Dahbash M, Sella R, Dardik R, Kenet G, Nisgav Y, Weinberger D.
    Exp Eye Res. 2019 Sep;186:107695. doi: 10.1016/j.exer.2019.107695. Epub 2019 Jun 12. PMID: 31201804.
    למחקר
  • Inflammation, angiogenesis and coagulation interplay in a variety of retinal diseases.
    Dan-Brezis I, Zahavi A, Axer-Siegel R, Nisgav Y, Dahbash M, Weinberger D, Ehrlich R, Livnat T.
    Acta Ophthalmol. 2019 Dec 12. doi: 10.1111/aos.14331. Epub ahead of print. PMID: 31833198.
    למחקר
  • Activated protein C induces suppression and regression of choroidal neovascularization- A murine model.
    Livnat T, Weinberger Y, Budnik I, Deitch I, Dahbash M, Sella R, Dardik R, Kenet G, Nisgav Y, Weinberger D.
    Exp Eye Res. 2019 Sep;186:107695.
    למחקר

2020

  • A Single Low-Dose of Methylphenidate Improves Abnormal Visual Field Testing.
    Sternfeld A, Bialer OY, Keidar D, Megiddo E, Budnik I, Stiebel-Kalish H, Livnat T.
    Curr Eye Res. 2020 Dec 21:1-8. doi: 10.1080/02713683.2020.1858430. Epub ahead of print. PMID: 33342320.
    למחקר
  • Investigating animal models of optic neuropathy: An accurate method for optic nerve and chiasm dissection in mice.
    Pozyuchenko K, Shouchane-Blum K, Brody J, Lazdon E, Yassur I, Nisgav Y, Frenkel D, Stiebel-Kalish H.
    J Neurosci Methods. 2020 Feb 1;331:108527. doi: 10.1016/j.jneumeth.2019.108527. Epub 2019 Nov 24. PMID: 31775012.
    למחקר
  • Punching a Graft for Descemet Membrane Endothelial Keratoplasty Onto a Contact Lens Reduces Endothelial Cell Loss at the Graft's Margin.
    Achiron A, Nahum Y, Adler A, Nisgav Y, Bahar I, Livny E.
    Cornea. 2020 Aug;39(8):1027-1030. doi: 10.1097/ICO.0000000000002342. PMID: 32384303.
    למחקר

2021

  • Regression of choroidal neovascularization (CNV) induced by activated protein C (APC) and 3K3A APC is mediated by VEGF reduction.
    Livnat T, Weinberger Y, Fernández JA, Bashir As, Ben-David G, Palevski D, Levy-Mendelovich S, Kenet G, Budnik I, Nisgav Y, Griffin JH, Weinberger D.
    Biomolecules. 2021 Feb 26;11(3):358.
    למחקר

2022

  • Genetic Alteration Analysis of IDH1, IDH2, CDKN2A, MYB and MYBL1 in Pediatric Low-Grade Gliomas.
    Barinfeld O*, Zahavi A*, Weiss S, Toledano H, Michowiz S, Goldenberg-Cohen N. (* Equal contribution).
    Front Surg. 2022 Apr 28;9:880048.
    למחקר
  • Histological and molecular characterization of glaucoma model induced by one or two injections of microbeads to the anterior chamber of mice.
    Zahavi A, Friedman Gohas M, Sternfeld A, Daoud Zreiq N, Muhsinoglu O, Ofri R, BarKana Y, Goldenberg-Cohen N.
    Int Ophthalmol. 2022 Jun 22. Epub ahead of print.
    למחקר
  • Trace Elements in Tears: Comparison of Rural and Urban Populations Using Particle Induced X-ray Emission.
    Girshevitz O, Cohen-Sinai N, Zahavi A, Vardizer Y, Fixler D, Goldenberg-Cohen N.
    J Pers Med. 2022 (Oct);12(10):1633.
    למחקר
  • Neuroprotective Effect of Azithromycin Following Induction of Optic Nerve Crush in Wild Type and Immunodeficient Mice.
    Zloto O*, Zahavi A*, Richard S, Friedman-Gohas M, Weiss S, Goldenberg-Cohen N. (* Equal contribution).
    Int J Mol Sci. 2022 Oct; 23(19):11872.
    למחקר
  • 3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation.
    Palevski D, Ben-David G, Weinberger Y, Haj Daood R, Fernández JA, Budnik I, Levy-Mendelovich S, Kenet G, Nisgav Y, Weinberger D, Griffin JH, Livnat T.
    Int J Mol Sci. 2022 (Nov) 2022 Nov 17;23(22):14196.
    למחקר

2023

  • Azithromycin and Sildenafil May Have Protective Effects on Retinal Ganglion Cells via Different Pathways: Study in a Rodent Microbeads
    Corina Sela T*, Zahavi A*, Friedman-Gohas M, Weiss S, Sternfeld A, Ilguisonis A, Badash D, Geffen N, Ofri R, BarKana Y, Goldenberg-Cohen N. (* Equal contribution).
    Model.Pharmaceuticals. 2023, 16(4), 486; https://doi.org/10.3390/ph16040486.
    למחקר
  • Characterization of Diabetic Retinopathy in Two Mouse Models and Response to a Single Injection of Anti-Vascular Endothelial Growth Factor.
    Azrad-Leibovich T, Zahavi A, Friedman-Gohas M, Brookman M, Barinfeld O, Muhsinoglu O, Michowiz S, Fixler D, Goldenberg-Cohen N. (Equal contribution).
    Int. J. Mol. Sci. 2023, 24, 324.
    למחקר
  • 3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina.
    Weinberger Y, Budnik I, Nisgav Y, Palevski D, Ben-David G, Fernández JA, Margalit SN, Levy-Mendelovich S, Kenet G, Weinberger D, Griffin JH, Livnat T.
    Int J Mol Sci. 2023 Jun 26;24(13):10642. doi: 10.3390/ijms241310642. PMID: 37445820; PMCID: PMC10341424.
    למחקר

2024

  • Structure-Function Correlation in Cobalt-Induced Brain Toxicity. Cells.
    Obied B, Richard S, Zahavi A, Fixler D, Girshevitz O, Goldenberg-Cohen N.
    2024 Oct 24;13(21):1765. doi: 10.3390/cells13211765. PMID: 39513872; PMCID: PMC11545114.
    למחקר
  • Cobalt Toxicity Induces Retinopathy and Optic Neuropathy in Mice.
    Obied B, Richard S, Zahavi A, Kreizman-Shefer H, Bajar J, Fixler D, Krmpotic M, Girshevitz O, Goldenberg-Cohen N.
    Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):59. doi: 10.1167/iovs.65.13.59. PMID: 39601637; PMCID: PMC11605662.
    למחקר
  • MicroRNAs as Biomarkers for Uveitis in Juvenile Idiopathic Arthritis. Ocul Immunol Inflamm.
    Sharon Y, Ben-David G, Nisgav Y, Amarilyo G, Shapira G, Israel-Elgali I, Pillar S, Pillar N, Shomron N, Kramer M.
    2024 Nov 19:1-7. doi: 10.1080/09273948.2024.2428417. Epub ahead of print. PMID: 39561030.
    למחקר

2025

  • Multi-Target Neuroprotective Effects of Flavonoid-Rich Ficus benjamina L. Leaf Extracts: Mitochondrial Modulation, Antioxidant Defense, and Retinal Ganglion Cell Survival In Vivo. Int
    Dahan A, Oz M, Yarmolinsky L, Zahavi A, Goldenberg Cohen N, Khalfin B, Ben-Shabat S, Lubin BC.
    J Mol Sci. 2025 Dec 4;26(23):11746.
    למחקר
  • Peripheral Blood Gene Expression Profiling in Proliferative Diabetic Retinopathy Using NanoString Technology.
    Zahavi A, Weiss S, Abu Dbai J, Salti T, Goldenberg-Cohen N.
    Diabetology. 2025;6(11):132.
    למחקר
  • Endothelial protein C receptor-mediated endogenous and therapeutic transport of activated protein C across the blood-retina barrier protects the retina.
    Livnat T, Budnik I, Nisgav Y, Dardik R, Avishai E, Rose Gonen S, Zahavi A, Fernández JA, Golderman V, Goldberg Z, Kenet G, Griffin J, Levy-Mendelovich S.
    J Thromb Haemost. 2025 Nov 18:S1538-7836(25)00836-0. (Online ahead of print).
    למחקר
  • Teprotumumab reduces the proliferation and viability of pterygium fibroblasts.
    Richard S, Obied B, Abu-Dbai J, Massalh J, Rabinovich Y, Vardizer Y, Zahavi A, Goldenberg-Cohen N.
    Exp Eye Res. 2025 Nov:260:110589.
    למחקר
  • Elemental composition analysis of sheep tears using particle-induced X-ray emission.
    Zahavi A, Pe’er O, Cohen Sinai N, Vardizer Y, Sebbag L, Ofri R, Girshevitz O, Goldenberg-Cohen N.
    Vet Ophthalmol. 2025 Oct 1. (Online ahead of print).
    למחקר
  • Molecular and Histological Characterization of a Novel Hydrogel-Based Strategy for Inducing Experimental Glaucoma in Mice.
    Obied B, Richard S, Kramarz Dadon J, Corina Sela T, Geffen N, Halperin-Sternfeld M, Adler-Abramovich L, Goldenberg-Cohen N, Zahavi A.
    Int J Mol Sci. 2025 Oct 10;26(20):9860.
    למחקר
  • Application of PIXE for Tear Analysis: Impact of Mineral Supplementation on Iron and Magnesium Levels in Athletes.
    Zobok T, Sheinfeld Y, Obied B, Vardizer Y, Zahavi A, Rabinovich Y, Girshevitz O, Shabi N, Fixler D, Goldenberg-Cohen N.
    Nutrients. 2025 Jun 16;17(12):2010.
    למחקר
  • Screening Blood and Vitreous for Biomarkers Associated with Proliferative Diabetic Retinopathy.
    Richard S, Kharouba R, Abudbai J, Gagarin O, Kratz A, Obied B, Zahavi A, Goldenberg-Cohen N.
    Diagnostics. 2025 May 27;15(11):1344.
    למחקר
  • In Vivo Imaging of Cobalt-Induced Ocular Toxicity in a Mouse Model. Methods
    Obied B, Saar G, Richard S, Rotenstreich Y, Sher Y, Zahavi A, Goldenberg-Cohen N.
    Protoc. 2025 Jan 2;8(1):1.
    למחקר

2026

  • Trace Element Levels in Canine Tear Film.
    Pe’er O, Sebbag L, Zahavi A, Girshevitz O, Goldenberg-Cohen N, Ofri R.
    Vet Ophthalmol. 2026 Jan;29(1):e70004.
    למחקר

Laboratory Head

Prof Yirit Bahar MD, MHA

Laboratory Head

Dr. Alon Zahavi

Laboratory Manager

Yael Nisgav

Research Team

  • Dr. Muhammad Darausheh

Students

  • Dr. Muhammad Darausheh
  • Dr. Shmuel Kagasov
  • Hala Afan

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