Telomeres and Telomerase Research

המעבדה לחקר הטלומרים והטלומראז
Head of the lab:
Prof. Pia Raanani and Dr. Boaz Tadmor
Phone: 03-9377906, 03-9376014
Lab Manager:
Dr. Orit Uziel
Phone: 03-9376796
Research team:
Students:
Research Areas:

Research topics

   In the past the Lab research focused on the biology of telomeres and telomerase.  Recently, the lab research results showed that telomerase mRNA is expressed in exosomes secreted from all types of cancer cells in vitro and in vivo. Exosomal telomerase is taken up by bystander cells e.g. fibroblasts, where it is translated into an active enzyme, converting them from telomerase-/- into telomerase+/+cells. Telomerase activity induces molecular changes promoting the transformation of them to become cancer associated fibroblasts (CAFs). 

   In light of the above findings the Lab research focuses now on the effects of chronic lymphocytic leukemia (CLL) cells – derived exosomes on their bystander cells: endothelial cells, monocytes and normal B cells. CLL derived exosomes induce the following changes: 

1.           Phosphorylate a plethora of proteins including b- catenin which induces IL-6 secretion into the endothelial cells growth medium. IL-6 is then taken up by the CLL cells where it activates STAT-3 providing CLL cells proliferative capabilities (Fig. 1).

2.           Induce the transformation of monocytes into nurse like cells.

3.           Induce the elimination of normal B cells (as a "Trojan horse") to take over common environmental resources (Fig. 2).

In addition, the Lab research focuses on following the levels of telomerase in exosomes of patients with brain tumors as well as breast and lung cancers in response to their clinical status.

CLL- derived exosomal vicious circle among endothelial cells

CLL- derived exosomal elimination of normal B cells (as Trojan horses)

Publications:
Contact details
Uziel Orit Mobile: 052-5784205
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